Is this the readme you got? :
$moddir=cstrike
LogD, MySQL, and Rcon lines in instruction 4 just ignore for now. You shouldn't have to edit modules.ini anyway.
The most important thing above is #3. Make sure you point metamod to amx.
If you can't get it working, let me know, or AIM me. The basics can be up relatively quick which covers most of what you're looking for, it's the tweaking and figuring out which plugins you'd like that can take a while.
Is it a Linux or Win32 server btw?