Yeah, I LOVE the side scroll! You can't accidentally hit it either, even when pressing down on the scroll wheel. If anything, you'll accidentally scroll down (or up) instead. So if you dont do that with your mouse currently, you wont do it with this one either.
Like was said before, the buttons are all programmable per application, so if you dont want to use the dpi, that's fine - just reprogram the buttons for whatever you want for whatever application. Side scroll alone is a GREAT selling point...
So yeah, anyway, both sides, the wheel itself, and the scroll down/up are all easy to use on my G5 and dont ever get confused accidentally.